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EPO Production

Echinacea angustifolia is an herb that stimulates the horse’s immune system and the horse’s kidneys to make more EPO. A daily dose of EPO Equine™ endurance horse supplement provides an extract of echinacea augustifolia in the amounts shown to significantly increase red blood cell production in horses.  This research was published in a peer-reviewed veterinary journal.

Peer Reviewed Published Data

Red Blood Cell Nutrients

To help the horse produce more red blood cells, you have to feed it the right raw materials. That’s why our scientists developed a specific formula of vitamins and minerals that ensure additional results in extra red blood cells nutrients. Included are Vitamin B-6, B-12, Folic Acid, B3, Boron and Inositol.

Here’s how certain vitamins and minerals can bolster red blood cell production:

Vitamin B-6 (Pyrodixine):  A red blood cell is useless without hemoglobin. That’s because hemoglobin is the part of a red blood cell that oxygen attaches to. Research published in the Journal of Biological Chemistry discovered that vitamin B6 is essential for hemoglobin to form. In other words, if the horse does not get enough vitamin B6, the horse’s red blood cells can’t carry the oxygen the horse needs.

B-12 and Folic Acid: If the horse is deficient in either vitamin B12 or folic acid new red blood cells are “born” misshapen and malfunctioning. This can actually make oxygen transport worse than before. That’s why the horse needs to get supplemental doses of both B12 and Folic Acid. The horse’s red blood cells will become the hard-working oxygen carriers they are supposed to be.

Vitamin B-3: Here’s another vitamin that the horse needs in order to pump out new, healthy red blood cells. A daily dose of Vitamin B-3 helps the horse produce new red blood cells at a faster clip.

Boron: Boron might not get a lot of press, but it’s emerging as a mineral that can help the horse. Its beneficial effects stem from the fact that boron can naturally help the horse’s body make more red blood cells than it could without extra Boron.

Inositol: The horse may be making more red blood cells, but it doesn’t mean that they’ll last. In fact, the lifespan of red blood cells is about 90 days. By taking Inositol 9,10 you’ll be creating stronger red blood cells – making them work longer for the horse.

Iron Availability

In reality, oxygen doesn’t bind directly to the red blood cell – it binds to the iron in hemoglobin in the red blood cell. Therefore, the horse needs several sources of dietary iron to make functioning red blood cells.

Iron: Proper iron intake ensures that red blood cells properly carry oxygen around the body. It’s been shown in numerous research studies that iron deficiency impairs oxygen transport and athletic performance. In fact, iron isn’t an ingredient that’s merely optimal for enhancing endurance – it’s absolutely necessary.

Dandelion and Yellow Dock: To get even more iron, it’s important for the horse to take these natural botanical extracts from two of the most iron-dense plants: dandelion and yellow dock. These two herbs ensure that the horse’s body gets enough iron for its brand new red blood cells.

Vitamin C, Vitamin B3, and Nickel: It’s one thing to take extra iron, but absorbing it from the gut is something else altogether. Believe it or not, but the horse’s body only absorbs about 10% of the iron that it eats. That is unless you supplement with vitamin C vitamin B3 and Nickel  – a trio of nutrients that help the horse’s body absorb more of the iron that it consumes.


After a particularly tough workout or competition the horse’s body has taken a big hit. Its muscles are worn and torn, its energy reserves are depleted, and its joints are flaring up from stress and strain. The horse’s body has one, and one way only, of dealing with all of this: inflammation.

Although inflammation is essential for recovery in small doses–unchecked inflammation makes recovering a real challenge. If you’ve ever had a period of time where the horse’s training suffered and it took forever to bounce back, it’s likely that inflammation was the culprit.

Worse yet, unchecked inflammation makes the horse’s body more prone to oxidation – a harmful process shown to get in the way of new muscle growth and adaptation to training. Not only that, but inflammation and oxidation can be roadblocks to new red blood cell development – causing a vicious cycle that slows the horse’s training.

Luckily, there are a handful of nutrients that are able to combat exercise-induced oxidation and inflammation; allowing the horse to move easier and increase the horse’s EPO production.

Alpha Lipoid Acid:  ALA  fights both inflammation and oxidation.

Lutein: Lutein is one of the most powerful antioxidants. Lutein can effectively fight oxidation and inflammation all over the horse’s body.

Lycopene: Like Lutein, Lycopene has been intensely researched. Lycopene, found in tomatoes, fights oxidation through a number of different pathways. This makes it a preferred antioxidant for performance horses.

Choline:   Choline is an amazing antioxidant. Not only does it fight oxidative damage, but according to a study out of the University of Lisbon, it actually improves blood flow and nitric oxide (NO) production. Nitric oxide is one of the most important chemicals for improving muscle contraction and increasing blood flow to muscles. 

PABA:   Along with its trademark antioxidant properties, PABA is able to make blood vessels more fluid – helping blood (and oxygen) travel to the horse’s fatigued muscles.